COLLASTAT
Bioactive collagen hemostat
- Faster and easier preparation
- Rapid and effective hemostasis
INDICATION
CollaStat is an absorbable hemostatic agent that is indicated in surgical procedures when control of bleeding by ligature or conventional procedures is ineffective or impractical, except in ophthalmic procedures. CollaStat is applicable in various bleeding site. [1 ~ 3]
Flow and Oozing
Steady Flow
Rapid and Spurting
SYNERGISTIC HEMOSTASIS ACTION OF COLLAGEN AND THROMBIN
● Collagen granules absorb blood and exudate into their porous structure and expand by 10~20%, leading to tamponade effect assisting hemostasis process.
● Collagen of CollaStat induces platelet adhesion and completes platelet activation with Von Willebrand Factor.
● Thrombin of CollaStat activates fibrinogen and turns it into fibrin.
10~20% expanded collagen after blood absorption
Synergistic Action of Collagen and Thrombin
CLINICAL STUDY – 1
Randomized clinical trial to evaluate hemostatic effect of collagen-based hemostat containing thrombin in spinal surgery [1]
: The hemostatic effect and safety of CollaStat has been proven in spinal surgery.
CLINICAL STUDY – 2
Randomized prospective clinical trial to evaluate hemostatic effect of collagen-based hemostat containing thrombin in thoracic surgery [2]
: The hemostatic effect and safety of CollaStat has been proven in cardiac surgery.
PRODUCT INFORMATION
|
Product Name |
CollaStat |
Item Name |
Collagen Hemostatic Agent |
|
Raw Materials |
Collagen, Thrombin, etc. |
Model Name / Volume |
DCF-17002 / 5 mL |
|
Storage Conditions |
2 – 25℃ (36 – 77℉) |
Shelf Life |
2 years from manufactured date |
COMPONENTS AND HOW TO USE
COMPONENTS AND HOW TO USE
▪ Allow 30 seconds before product application after mixing.
▪ Do not inject or compress CollaStat into blood vessels.
▪ If bleeding has ceased, excess CollaStat (not incorporated in the hemostatic clot) should always be removed by gentle irrigation and suctioned from the application site.
※ References:
[1] Sang Man Park et al., Efficacy and Safety of a Thrombin-Containing Collagen-Based Hemostatic Agent in Spinal Surgery: A Randomized Clinical Trial, World Neurosurgery (2021), E1-E7.
[2] Randomized prospective clinical trial to evaluate hemostatic effect of collagen-based hemostat containing thrombin in thoracic surgery, Young-Nam Youn, MD, PhD (Dep. of Thoracic and Cardiovascular Surgery, Yonsei University Medical Center).
[3] Yejong Park et al., Effect of Flowable Thrombin-Containing Collagen-Based Hemostatic Matrix for Preventing Pancreatic Fistula after Pancreatectomy: A Randomized Clinical Trial, J. Clin. Med. 2020, 9, 3085.